Carvacrol, sodyum arsenit kaynaklı ince bağırsak toksisitesini iyileştirmektedir

Arsenic is a very dangerous metal that widely distributed in the environment as result of anthropogenic and natural processes. On other hand, it thought treatment with flavonoids may protect against arsenic toxicity. Carvacrol (CRV) naturally occurring phenolic compound anti-inflammatory, anti-apoptotic, antioxidant properties. This study aims to investigate protective effects CRV on sodium arsenite (SA)-induced intestinal For this purpose, rats were randomly divided into five groups administered SA orally for 14 days. The data indicate when administered, lipid peroxidation increase enzyme activities decrease. administration ameliorated impairment defense system. Examining expression levels NF-kB IL-1 revealed inflammation increased application but decreased administration. Moreover, Caspase-3 Apaf1 treated SA, whereas severity apoptosis was administered. In light these findings, possible state protects tissues from damage by presenting antioxidant, anti-apoptotic SA-induced